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BRCA Hot Spot Screening

The BRCA genes (BRCA1 and BRCA2) are tumor suppressor gene which acts as caretaker of the genome and maintain the integrity with its role in DNA synthesis and repair. Do you know that person who have inherited mutations in these genes are at an increased risk of developing breast cancer (both male and female), ovarian cancer (in female), prostate cancer (in male) and pancreatic cancer (both male and female) as compared with the general population.A BRCA gene mutation screening will determine whether you carry an inherited BRCA mutation. Most people considering genetic testing undergo genetic counseling, which can help you understand what the results could mean for your health and help you decide whether genetic testing is right for you. In general population having a mutation in BRCA gene is rare but inherited mutations in BRCA genes are responsible cancer in breast, ovary and prostate. Mutations in either of the BRCA gene (BRCA1 or BRCA2) significantly increase your risk of developing breast, ovarian or prostate cancer when compared with the person without a BRCA gene mutation. Once detected, and depending on the type of mutation, therapeutic and surgical options are available for reducing the risk of cancer. The life time risk of Breast cancer also can be managed for life time after detecting the type change inherited in the Breast cancer gene.


Who should consider BRCA gene testing?

  • A personal history of breast cancer diagnosed at a young age (premenopausal or younger than age 50)
  • A personal history of triple negative breast cancer diagnosed at age 60 or younger
  • A personal history of breast cancer affecting both breasts (bilateral breast cancer)
  • A personal history of both breast and ovarian cancers
  • A personal history of ovarian cancer
  • A personal history of prostate cancer (in male)
  • A personal history of breast cancer and one or more relatives with breast cancer diagnosed at age 50 or younger, one relative with ovarian cancer, or two or more relatives with breast or pancreatic cancer
  • A history of breast cancer at a young age in two or more close relatives, such as your parents, siblings or children
  • A male relative with breast cancer
  • A family member who has both breast and ovarian cancers
  • A family member with bilateral breast cancer
  • A relative with ovarian cancer
  • A relative with a known BRCA1 or BRCA2 mutation
  • Ashkenazi (Eastern European) Jewish ancestry, with a close relative who has breast, ovarian or pancreatic cancer at any age